Cancer can upset a patient suffering from it as it cannot be cured. Much research is on to find a cure but so far no way out has been found.

Cancer happens to be a deadly disease and cannot be cured. The patient gets upset as he or she knows that coping up with the treatment procedure is difficult. Research has been on to find a cure for it.

How Leukemia affects us?

Leukemia stem cells tend to protect themselves against the immune defense by actually suppressing a target molecule for killer cells. This can be done with the help of drugs. The focus is on making cancer stem cells visible to the immune system.

Patients with acute myeloid leukemia (AML) do get into relapse after apparently undergoing successful treatment. Leukemia stem cells that happen to survive the therapy are responsible for the return of the disease. The stem cells are protective mechanisms that do make them resistant to chemotherapy. The question that arises is how do they manage to escape the immune defense? Is it making cancer stem cells visible to the immune system?

Analysis of Leukemia cells:

Researchers conducted an analysis of leukemia cells of 175 AML patients and have found that the cancer stem cells do suppress the NKG2D-L proteins on the surface. These proteins do enable the natural killer cells (NK cells) to identify damage as well as infected cells as well as cancer cells and then kill them if required. In this way, the leukemia stem cells do escape destruction by the immune system. Leukemia cells which do not have stem cell properties, on the other hand, do present these target molecules on their surface and are thus kept in check by the NK cells.
An important mechanism of this immune resistance in leukemia stem cells involves the suppression of danger signals such as NKG2D-L on the cell surface. Efforts are on to making cancer stem cells visible to the immune system.

also read: Guide To Strengthen Immunity system

More about Leukemia stem cells:

What is behind this extraordinary protective mechanism? The scientists have observed that leukemia stem cells do produce a particularly high amount of PARP1, an enzyme that does apparently block NKG2D-L production. Preclinical experiments with mice to which human leukemia cells had been transferred showed that PARP1 actually does play an important role in immune escape: If these animals were treated with drugs that inhibit PARP1, the leukemia stem cells do tend to expressed NKG2D-L on their surface and were then taken note of and eliminated by NK cells. All these efforts are for making cancer stem cells visible to the immune system.

Cancer therapies that entail the immune system have been successfully applied for several years in allogeneic stem cell transplantation from AML patients in certain diseases. Off late there have been immunotherapeutic approaches that have been developed which are currently being clinically tested. Cancer stem cells do trick the immune system. By observing the underlying mechanism it is possible to counterattack. Thus perhaps it is possible in making cancer stem cells visible to the immune system.

The results do provide the foundation for the possibility of combating malignant leukemia stem cells by combining PARP inhibitors with the help of active NK cells. A clinical approach will be taken towards this end.

Pre-diabetes needs to be tackled sensibly to prevent diabetes and it is good to control one’s dietary habits and thus maintain good health. Exercise helps.

Researchers at the Karolinska Institute’s Aging Research Center in Stockholm have revealed in a study that people who do suffer from pre-diabetes are indeed less likely to develop diabetes, thus returning to normal blood sugar levels. Here You can know Symptoms of Low Blood Sugar

This is indeed good to know and people will be less worried about their pre-diabetes diagnosis, experts state that lifestyle. Lifestyle changes do help.

A person with pre-diabetes does suffer from high blood sugar levels, so they do need to limit their sugar intake as much as possible to control the levels and also further prevent the risk of diabetes.

One does need to choose the right sort of food; in other words, one does need to eat healthily. Diet does matter as far as pre-diabetes is concerned. One must avoid sugar foods and not eat foods high in carbohydrates and have more protein as one grows older.

The diagnosis reversal can also be taken care of by maintaining a diet high in fiber, grains, and vegetables as well as a regular exercise routine. Cutting carbs, as well as processed foods from one’s daily diet, are also suggested for the same.

Older adults with pre-diabetes remain stable or reverted to normoglycaemia according to research study, whereas few develop diabetes.

The researchers do believe that having lower systolic blood pressure, no heart disease, and manageable weight does indeed help in the reversal of the diagnosis.

However, researchers have indeed cautioned that a pre-diabetes reversal is not a cure.

During a 12-year follow-up, most older adults with pre-diabetes do remain stable or reverted to normoglycaemia, whereas only one-third developed diabetes or died according to the researchers.

The researchers do believe that having lower systolic blood pressure, no heart disease and manageable weight does help in the reversal of diagnosis. However, researchers have cautioned that a pre-diabetes reversal is not a cure as it does need to be maintained.

Those suffering from diabetes have to change their lifestyle habits to maintain control over it. It is obvious in case a person suffers from pre-diabetes it is necessary to take the required precautions to prevent the disease from occurring. It does require a lot of will power. Diet and exercise are essential and healthy weight levels need to be maintained.

Obesity is a health issue and can cause Type 2 diabetes and therefore pre-diabetes conditions should not be ignored. also read: Homeopathic Medicines for Obesity

Researchers do advice that precaution taken at the pre-diabetes level does help prevent the occurrence of diabetes although it is also genetic.
Staying healthy after certain is difficult but by regulating one’s food habits one can indeed be able to maintain better health. Seeking medical advice regarding diet and lifestyle changes do help. Rather than deciding for oneself what to eat, it is advisable to eat what a dietician prescribes in case a person is keen to lose weight.
Take adequate rest, eat right and follow a regular exercise routine to maintain blood sugar levels.

Obesity is a health issue which several people face and they try their level best to reduce as it could lead to other health complications. Medical advice needs to be taken.

Obesity has been affecting many all over the world and is on the increase. Therefore should obesity be recognized as a disease? Obesity happens to be a health condition whereby excess body fat has accumulated to such an extent that health may indeed be adversely affected.

It is understood that nearly 200 genes influence weight, and most of these are expressed in the brain or adipose tissue. It involves body weight, fat distribution, and risk of complications which are influenced by our biological get-up. It is not an individual’s fault if one develops obesity.

They do indeed feel that the recent rapid increase in obesity is not on account of genetics but to an altered environment (food availability as well as cost, physical environment, as well as social factors).
Many feel that obesity happens to be self-inflicted and that the individual affected can do something about it. Healthcare professionals do feel obesity is a complex issue. It is felt that obesity is recognized as a disease.

Obesity is a chronic disease comes along with severe complications rather than a lifestyle choice and helps reduce the stigma and discrimination that is experienced by several people with obesity.
Other common diseases, like high blood pressure as well as diabetes, are managed by people and require action to be taken by them. also read: Different types of skin diseases

The opinion is held that most people with obesity will eventually develop complications and therefore obesity be recognized as a disease. It seems so that unless and until obesity is acknowledged as a disease, one cannot curb the epidemic.

By dictionary standards, obesity is considered to be a disease and requires medical attention. Obesity cannot be considered to be harmless.

Psychologically one does feel bad about it and is concerned about the health risk involved by suffering from it.

Healthcare providers can deal with it and it can be treated the natural way through diet and exercise and also via drugs and surgery.

Self-determination helps in combating obesity. Obesity is social problems are social and solutions are there. Group activity helps rather than leading an isolated life. In case, obesity is neglected it leads to complications.  There are Homeopathic Medicines for Obesity.

People believe that obesity is self-inflicted and that it is entirely the individual’s responsibility to do something about it, while healthcare professionals are indeed ill-informed on the complexity of obesity as well as what patients with obesity want.

Recognizing obesity being recognized as a chronic disease with severe complications rather than a lifestyle choice it can help reduce the stigma and discrimination experienced by many people who suffer from obesity.

Obese people are very conscious about being fat and do take required medical advice to get rid of it. No doubt, apart from food, there are other underlying medical conditions such as hypothyroidism. Yet one needs to change their lifestyle and also eat healthy foods rather than fried food. Slimming down requires patience and care of course.

Dengue can cause much risk to one’s health and there are several breeding grounds for these dengue mosquitoes. Older people, children, and pregnant women are vulnerable.

Dengue is one of the most important mosquito-borne arboviral diseases in the tropics. It is caused by a flavivirus, transmitted by the bite of the infected Aedes aegypti and Aedes albopictus mosquito, which does breed in clean stagnant water. It is one of the reasons behind rising in dengue.

Malaria, as well as dengue, is rampant during the monsoon. Over the past couple of years, cases of malaria have indeed gone down, but dengue does not seem to abate. Also, the severity of dengue has indeed increased in the past couple of years on account of several factors including the mutation of the virus.

Why cases are on the rise?

Dengue fever does provide an ideal case study regarding urbanization as well as globalization that does influence infectious disease emergence. Dengue occurs during periods of heavy rainfall interspersed with dry weather. Aedes aegypti happens to be a highly domesticated urban mosquito that does prefer to live with humans in their homes. They feed on humans and lay eggs in artificial containers that happen to be made by humans that are made by humans. It does bite several individuals during a single blood meal.

The areas where dengue mosquitoes breed are automobile tires, plastic containers, drums filled with water, coolers, etc. which happen to be found in the crowded urban environment which is considered to be high mosquito population densities. Dengue mosquito that breeds inside houses has gone up by 27% in the last year and dengue cases within the state have increased by 41% in just one year. Also, rampant authorized, as well as unauthorized construction, has indeed led to the rise in dengue cases. These are some of the reasons behind rising in dengue.

Symptoms

Dengue symptoms are in the form of high fever, severe body ache, headache, rash, conjunctional congestion, and bleeding manifestations.

Groups of people who are vulnerable such as old age people, children, pregnant women and people with comorbidities such as hypertension, diabetes, cardiac conditions, etc may have severe symptoms and a higher rate of complications.

Also read: Tips to Prevent Dengue Fever

Most people do respond to a simple form of measures such as plenty of oral fluids as well as paracetamol for the fever. Non-steroidal, anti-inflammatory drugs such as ibuprofen, diclofenac, etc. need to be avoided as they do contribute to the thrombocytopenia (low platelet count) that is seen in patients. Such measures need to be taken to counter the reasons behind rising in dengue.
It is essential to watch out for warning signs such as unresponsive fever, severe vomiting, abdominal pain, breathlessness, loss of consciousness, bleeding from the nose, mouth, etc and hospitalize such patients.

Precaution is key

Dengue is not contagious and does not spread from person to person. However, febrile patients do protect themselves from mosquito bites as the mosquito can ingest the virus from the patient and also become infective to the next victim. Bleeding in dengue patients is multi-factorial and low platelet count is just one of the causes.

Active bleeding due to thrombocytopenia does occur only when the platelet count is less than 10,000/cm (Normal range 1.5 to 4 lakhs/cm). So a low platelet count need not cause a panic situation, especially if more than 1 lakh/cm. Unnecessary platelet transfusion has its hazards and also creates a shortage of deserving patients.

Dengue can be indeed prevented by averting mosquito breeding in and around the house, by regularly emptying water-filled containers and also avoiding mosquito bites by using mosquito repellants and coils, especially when febrile.

Fevers in monsoons should not be taken lightly and when warning signs are visible, a visit to the physician is important, for hospitalization if necessary. There is no antiviral medicine or vaccine available for dengue as of now.

Also read: Symptoms treatment and Causes Of Dengue fever